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Winfrey debuted as Sofia, an assertive woman living a difficult life in early 20th century America, in Steven Spielberg's adaptation of an Alice Walker novel. The performance earned her an Oscar nomination.
Adapted from a Toni Morrison novel, this was a film directed by Jonathan Demme that Winfrey produced and starred in, playing a former slave who encounters spirits and is also dealing with the passing of her daughter.
Winfrey voiced Gussy the Goose, one half of a kindly goose couple, in this live action-animation film by Gary Winick.
Winfrey lent her voice to Eudora, the protagonist's mother, and also served as a consultant on one of the first major animated productions by Disney to feature Black characters.
Winfrey played Gloria Gaines, wife to the titular character, in Lee Daniels' drama of what goes on in the White House.
Winfrey produced and starred in the Civil Rights drama helmed by Ava DuVernay, playing activist Annie Lee Cooper to great acclaim.
Winfrey played the daughter of the titular Henrietta Lacks, whose cells from her battle with cervical cancer altered forever the course of cancer treatment.